Causality between local field potentials of the subthalamic nucleus and electromyograms of forearm muscles in Parkinson’s disease
Identifieur interne : 001670 ( Main/Corpus ); précédent : 001669; suivant : 001671Causality between local field potentials of the subthalamic nucleus and electromyograms of forearm muscles in Parkinson’s disease
Auteurs : Esther Florin ; Joachim Gross ; Christiane Reck ; Mohammad Maarouf ; Alfons Schnitzler ; Volker Sturm ; Gereon R. Fink ; Lars TimmermannSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2010-02.
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Abstract
Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson’s disease, although its precise mechanisms remain poorly understood. To gain further insight into the mechanisms underlying deep brain stimulation, we analysed the causal relationship between forearm muscle activity and local field potentials derived from the subthalamic nucleus. In 19 patients suffering from Parkinson’s disease of the akinetic‐rigid subtype, we calculated the squared partial directed coherence between muscles of the contralateral forearm and the subthalamic nucleus or zona incerta during both a rest and a hold condition of the arm. For both recording regions, data analysis revealed that, during the rest condition, electromyographic activity was significantly more often ‘Granger‐causal’ for the local field potentials than the opposite causation. In contrast, during the hold condition, no significant difference was found in the occurrence of causalities. Contrary to the existing basal ganglia model and the current concept of Parkinson’s disease pathophysiology, we found the subthalamic nucleus to receive more ‘afferences’ than it emitted ‘efferences’, suggesting that its role is more complex than a simple driving nucleus in the basal ganglia loop. Therefore, the effect of deep brain stimulation in the subthalamic nucleus could, at least in part, result from a blockade of pathological afferent input.
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DOI: 10.1111/j.1460-9568.2010.07083.x
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To gain further insight into the mechanisms underlying deep brain stimulation, we analysed the causal relationship between forearm muscle activity and local field potentials derived from the subthalamic nucleus. In 19 patients suffering from Parkinson’s disease of the akinetic‐rigid subtype, we calculated the squared partial directed coherence between muscles of the contralateral forearm and the subthalamic nucleus or zona incerta during both a rest and a hold condition of the arm. For both recording regions, data analysis revealed that, during the rest condition, electromyographic activity was significantly more often ‘Granger‐causal’ for the local field potentials than the opposite causation. In contrast, during the hold condition, no significant difference was found in the occurrence of causalities. Contrary to the existing basal ganglia model and the current concept of Parkinson’s disease pathophysiology, we found the subthalamic nucleus to receive more ‘afferences’ than it emitted ‘efferences’, suggesting that its role is more complex than a simple driving nucleus in the basal ganglia loop. Therefore, the effect of deep brain stimulation in the subthalamic nucleus could, at least in part, result from a blockade of pathological afferent input.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Esther Florin</name><affiliations><json:string>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</json:string><json:string>Institute of Neurosciences and Medicine (INM‐3), Cognitive Neurology Section, Forschungszentrum Jülich, Leo‐Brandt‐Strasse 5, 52425 Jülich, Germany</json:string></affiliations></json:item><json:item><name>Joachim Gross</name><affiliations><json:string>Centre for Cognitive Neuroimaging, Department of Psychology, University of Glasgow, Glasgow, UK</json:string></affiliations></json:item><json:item><name>Christiane Reck</name><affiliations><json:string>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</json:string></affiliations></json:item><json:item><name>Mohammad Maarouf</name><affiliations><json:string>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Köln, Germany</json:string></affiliations></json:item><json:item><name>Alfons Schnitzler</name><affiliations><json:string>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine‐University, Düsseldorf, Germany</json:string><json:string>Department of Neurology, Heinrich‐Heine‐University, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>Volker Sturm</name><affiliations><json:string>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Köln, Germany</json:string></affiliations></json:item><json:item><name>Gereon R. 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To gain further insight into the mechanisms underlying deep brain stimulation, we analysed the causal relationship between forearm muscle activity and local field potentials derived from the subthalamic nucleus. In 19 patients suffering from Parkinson’s disease of the akinetic‐rigid subtype, we calculated the squared partial directed coherence between muscles of the contralateral forearm and the subthalamic nucleus or zona incerta during both a rest and a hold condition of the arm. For both recording regions, data analysis revealed that, during the rest condition, electromyographic activity was significantly more often ‘Granger‐causal’ for the local field potentials than the opposite causation. In contrast, during the hold condition, no significant difference was found in the occurrence of causalities. Contrary to the existing basal ganglia model and the current concept of Parkinson’s disease pathophysiology, we found the subthalamic nucleus to receive more ‘afferences’ than it emitted ‘efferences’, suggesting that its role is more complex than a simple driving nucleus in the basal ganglia loop. 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Neuroimaging, Department of Psychology, University of Glasgow, Glasgow, UK</affiliation></author><author><persName><forename type="first">Christiane</forename><surname>Reck</surname></persName><affiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</affiliation></author><author><persName><forename type="first">Mohammad</forename><surname>Maarouf</surname></persName><affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Köln, Germany</affiliation></author><author><persName><forename type="first">Alfons</forename><surname>Schnitzler</surname></persName><affiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation><affiliation>Department of Neurology, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation></author><author><persName><forename type="first">Volker</forename><surname>Sturm</surname></persName><affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Köln, Germany</affiliation></author><author><persName><forename type="first">Gereon R.</forename><surname>Fink</surname></persName><affiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</affiliation><affiliation>Institute of Neurosciences and Medicine (INM‐3), Cognitive Neurology Section, Forschungszentrum Jülich, Leo‐Brandt‐Strasse 5, 52425 Jülich, Germany</affiliation></author><author><persName><forename type="first">Lars</forename><surname>Timmermann</surname></persName><affiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</affiliation></author></analytic><monogr><title level="j">European Journal of Neuroscience</title><idno type="pISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><idno type="DOI">10.1111/(ISSN)1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-02"></date><biblScope unit="volume">31</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="491">491</biblScope><biblScope unit="page" to="498">498</biblScope></imprint></monogr><idno type="istex">CFEA308A2A096B779A189AE6F0E33DD8F8F7BFB6</idno><idno type="DOI">10.1111/j.1460-9568.2010.07083.x</idno><idno type="ArticleID">EJN7083</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson’s disease, although its precise mechanisms remain poorly understood. To gain further insight into the mechanisms underlying deep brain stimulation, we analysed the causal relationship between forearm muscle activity and local field potentials derived from the subthalamic nucleus. In 19 patients suffering from Parkinson’s disease of the akinetic‐rigid subtype, we calculated the squared partial directed coherence between muscles of the contralateral forearm and the subthalamic nucleus or zona incerta during both a rest and a hold condition of the arm. For both recording regions, data analysis revealed that, during the rest condition, electromyographic activity was significantly more often ‘Granger‐causal’ for the local field potentials than the opposite causation. In contrast, during the hold condition, no significant difference was found in the occurrence of causalities. Contrary to the existing basal ganglia model and the current concept of Parkinson’s disease pathophysiology, we found the subthalamic nucleus to receive more ‘afferences’ than it emitted ‘efferences’, suggesting that its role is more complex than a simple driving nucleus in the basal ganglia loop. Therefore, the effect of deep brain stimulation in the subthalamic nucleus could, at least in part, result from a blockade of pathological afferent input.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>deep brain stimulation</term></item><item><term>Granger</term></item><item><term>local field potentials</term></item><item><term>squared partial directed coherence</term></item><item><term>subthalamic nucleus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-02">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/CFEA308A2A096B779A189AE6F0E33DD8F8F7BFB6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1460-9568</doi><issn type="print">0953-816X</issn><issn type="electronic">1460-9568</issn><idGroup><id type="product" value="EJN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROSCIENCE">European Journal of Neuroscience</title></titleGroup></publicationMeta><publicationMeta level="part" position="02003"><doi origin="wiley">10.1111/ejn.2010.31.issue-3</doi><numberingGroup><numbering type="journalVolume" number="31">31</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2010-02">February 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="9" status="forIssue"><doi origin="wiley">10.1111/j.1460-9568.2010.07083.x</doi><idGroup><id type="unit" value="EJN7083"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">NEUROSYSTEMS</title></titleGroup><copyright>© The Authors (2010). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</copyright><eventGroup><event type="firstOnline" date="2010-01-25"></event><event type="publishedOnlineFinalForm" date="2010-02-01"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-02"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="491">491</numbering><numbering type="pageLast" number="498">498</numbering></numberingGroup><correspondenceTo>Professor Dr Lars Timmermann, <sup>1</sup>Department of Neurology; Dr Esther Florin, <sup>2</sup>Institute of Neurosciences and Medicine (INM‐3), as above.
E‐mails: <email normalForm="Lars.Timmermann@uk-koeln.de">Lars.Timmermann@uk‐koeln.de</email>; <email normalForm="e.florin@fz-juelich.de">e.florin@fz‐juelich.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJN.EJN7083.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 21 July 2009, revised 26 November 2009, accepted 2 December 2009</unparsedEditorialHistory><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Causality between local field potentials of the subthalamic nucleus and electromyograms of forearm muscles in Parkinson’s disease</title><title type="shortAuthors">E. Florin <i>et al.</i></title><title type="short">Causality in Parkinson’s disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Esther</givenNames><familyName>Florin</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>Joachim</givenNames><familyName>Gross</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Christiane</givenNames><familyName>Reck</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>Mohammad</givenNames><familyName>Maarouf</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5 #a6"><personName><givenNames>Alfons</givenNames><familyName>Schnitzler</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a4"><personName><givenNames>Volker</givenNames><familyName>Sturm</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1 #a2"><personName><givenNames>Gereon R.</givenNames><familyName>Fink</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1"><personName><givenNames>Lars</givenNames><familyName>Timmermann</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>Institute of Neurosciences and Medicine (INM‐3), Cognitive Neurology Section, Forschungszentrum Jülich, Leo‐Brandt‐Strasse 5, 52425 Jülich, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="GB"><unparsedAffiliation>Centre for Cognitive Neuroimaging, Department of Psychology, University of Glasgow, Glasgow, UK</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="DE"><unparsedAffiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Köln, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="DE"><unparsedAffiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine‐University, Düsseldorf, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="DE"><unparsedAffiliation>Department of Neurology, Heinrich‐Heine‐University, Düsseldorf, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">deep brain stimulation</keyword><keyword xml:id="k2">Granger</keyword><keyword xml:id="k3">local field potentials</keyword><keyword xml:id="k4">squared partial directed coherence</keyword><keyword xml:id="k5">subthalamic nucleus</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson’s disease, although its precise mechanisms remain poorly understood. To gain further insight into the mechanisms underlying deep brain stimulation, we analysed the causal relationship between forearm muscle activity and local field potentials derived from the subthalamic nucleus. In 19 patients suffering from Parkinson’s disease of the akinetic‐rigid subtype, we calculated the squared partial directed coherence between muscles of the contralateral forearm and the subthalamic nucleus or zona incerta during both a rest and a hold condition of the arm. For both recording regions, data analysis revealed that, during the rest condition, electromyographic activity was significantly more often ‘Granger‐causal’ for the local field potentials than the opposite causation. In contrast, during the hold condition, no significant difference was found in the occurrence of causalities. Contrary to the existing basal ganglia model and the current concept of Parkinson’s disease pathophysiology, we found the subthalamic nucleus to receive more ‘afferences’ than it emitted ‘efferences’, suggesting that its role is more complex than a simple driving nucleus in the basal ganglia loop. Therefore, the effect of deep brain stimulation in the subthalamic nucleus could, at least in part, result from a blockade of pathological afferent input.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Causality between local field potentials of the subthalamic nucleus and electromyograms of forearm muscles in Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>Causality in Parkinson’s disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Causality between local field potentials of the subthalamic nucleus and electromyograms of forearm muscles in Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">Esther</namePart><namePart type="family">Florin</namePart><affiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</affiliation><affiliation>Institute of Neurosciences and Medicine (INM‐3), Cognitive Neurology Section, Forschungszentrum Jülich, Leo‐Brandt‐Strasse 5, 52425 Jülich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joachim</namePart><namePart type="family">Gross</namePart><affiliation>Centre for Cognitive Neuroimaging, Department of Psychology, University of Glasgow, Glasgow, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christiane</namePart><namePart type="family">Reck</namePart><affiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mohammad</namePart><namePart type="family">Maarouf</namePart><affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Köln, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfons</namePart><namePart type="family">Schnitzler</namePart><affiliation>Department of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation><affiliation>Department of Neurology, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Volker</namePart><namePart type="family">Sturm</namePart><affiliation>Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Köln, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gereon R.</namePart><namePart type="family">Fink</namePart><affiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</affiliation><affiliation>Institute of Neurosciences and Medicine (INM‐3), Cognitive Neurology Section, Forschungszentrum Jülich, Leo‐Brandt‐Strasse 5, 52425 Jülich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Timmermann</namePart><affiliation>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, 50937 Köln, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-02</dateIssued><edition>Received 21 July 2009, revised 26 November 2009, accepted 2 December 2009</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">3</extent></physicalDescription><abstract lang="en">Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson’s disease, although its precise mechanisms remain poorly understood. To gain further insight into the mechanisms underlying deep brain stimulation, we analysed the causal relationship between forearm muscle activity and local field potentials derived from the subthalamic nucleus. In 19 patients suffering from Parkinson’s disease of the akinetic‐rigid subtype, we calculated the squared partial directed coherence between muscles of the contralateral forearm and the subthalamic nucleus or zona incerta during both a rest and a hold condition of the arm. For both recording regions, data analysis revealed that, during the rest condition, electromyographic activity was significantly more often ‘Granger‐causal’ for the local field potentials than the opposite causation. In contrast, during the hold condition, no significant difference was found in the occurrence of causalities. Contrary to the existing basal ganglia model and the current concept of Parkinson’s disease pathophysiology, we found the subthalamic nucleus to receive more ‘afferences’ than it emitted ‘efferences’, suggesting that its role is more complex than a simple driving nucleus in the basal ganglia loop. Therefore, the effect of deep brain stimulation in the subthalamic nucleus could, at least in part, result from a blockade of pathological afferent input.</abstract><subject lang="en"><genre>Keywords</genre><topic>deep brain stimulation</topic><topic>Granger</topic><topic>local field potentials</topic><topic>squared partial directed coherence</topic><topic>subthalamic nucleus</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0953-816X</identifier><identifier type="eISSN">1460-9568</identifier><identifier type="DOI">10.1111/(ISSN)1460-9568</identifier><identifier type="PublisherID">EJN</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>491</start><end>498</end><total>8</total></extent></part></relatedItem><identifier type="istex">CFEA308A2A096B779A189AE6F0E33DD8F8F7BFB6</identifier><identifier type="DOI">10.1111/j.1460-9568.2010.07083.x</identifier><identifier type="ArticleID">EJN7083</identifier><accessCondition type="use and reproduction" contentType="copyright">© The Authors (2010). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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